Drug interactions
Lisdexamfetamine + Rabeprazole
Severity: Minor
Lisdexamfetamine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression with a proton pump inhibitor can alter the absorption profile of amphetamine released from lisdexamfetamine, with an earlier time to peak concentration. Total exposure is essentially unchanged, so the clinical effect is expected to be small.
What this interaction means in plain words
Lisdexamfetamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH slightly changes the rate of amphetamine absorption without changing overall exposure.
What to do
No dose change is usually needed; monitor clinical response and adjust lisdexamfetamine only if effect changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Rabeprazole?
MediHelp rates the interaction as minor. Lisdexamfetamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression with a proton pump inhibitor can alter the absorption profile of amphetamine released from lisdexamfetamine, with an earlier time to peak concentration. Total exposure is essentially unchanged, so the clinical effect is expected to be small.
How serious is the interaction between Lisdexamfetamine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor clinical response and adjust lisdexamfetamine only if effect changes.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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