Drug interactions
Lisdexamfetamine + Scullcap
Severity: Minor
Lisdexamfetamine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap is an herbal product traditionally used for its calming effects and may add to sedation from other CNS depressants, while lisdexamfetamine is stimulating. Clinical data on this pairing are essentially lacking, and the effect is largely theoretical.
What this interaction means in plain words
Lisdexamfetamine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical opposing CNS effects; the herbal product's sedative action is poorly characterized and no mechanism is established.
What to do
Ask patients about herbal supplement use and advise against relying on scullcap for sleep during stimulant therapy. Monitor for changes in sleep or anxiety.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Scullcap?
MediHelp rates the interaction as minor. Lisdexamfetamine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Scullcap is an herbal product traditionally used for its calming effects and may add to sedation from other CNS depressants, while lisdexamfetamine is stimulating. Clinical data on this pairing are essentially lacking, and the effect is largely theoretical.
How serious is the interaction between Lisdexamfetamine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal supplement use and advise against relying on scullcap for sleep during stimulant therapy. Monitor for changes in sleep or anxiety.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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