Drug interactions
Lisdexamfetamine + Selegiline transdermal
Severity: Contraindicated
Lisdexamfetamine and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining amphetamines with an MAO inhibitor can cause a massive release of norepinephrine and dopamine that cannot be metabolized. This can cause hypertensive crisis, hyperthermia, arrhythmia and serotonin toxicity.
What this interaction means in plain words
Lisdexamfetamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition blocks amine breakdown while amphetamine promotes release of catecholamines and serotonin.
What to do
Do not co-administer, and separate by at least 14 days after stopping an MAO inhibitor before starting lisdexamfetamine. Use a non-amphetamine option, and treat any hypertensive or serotonergic emergency immediately.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Lisdexamfetamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining amphetamines with an MAO inhibitor can cause a massive release of norepinephrine and dopamine that cannot be metabolized. This can cause hypertensive crisis, hyperthermia, arrhythmia and serotonin toxicity.
How serious is the interaction between Lisdexamfetamine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and separate by at least 14 days after stopping an MAO inhibitor before starting lisdexamfetamine. Use a non-amphetamine option, and treat any hypertensive or serotonergic emergency immediately.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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