Drug interactions
Lisdexamfetamine + Sufentanil sl
Severity: Moderate
Lisdexamfetamine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin, and opioids have been rarely linked to serotonin syndrome, so combining them may add some risk. Sublingual sufentanil also causes sedation and respiratory depression that a stimulant will not reliably offset.
What this interaction means in plain words
Lisdexamfetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects, plus opposing CNS effects on sedation.
What to do
Monitor for agitation, tremor, hyperthermia and clonus, especially at initiation and dose changes. Assess respiratory status objectively and do not rely on patient alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Sufentanil sl?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic serotonin, and opioids have been rarely linked to serotonin syndrome, so combining them may add some risk. Sublingual sufentanil also causes sedation and respiratory depression that a stimulant will not reliably offset.
How serious is the interaction between Lisdexamfetamine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and clonus, especially at initiation and dose changes. Assess respiratory status objectively and do not rely on patient alertness.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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