Drug interactions
Lisdexamfetamine + Triazolam
Severity: Minor
Lisdexamfetamine and Triazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a short-acting benzodiazepine hypnotic, whereas lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask sedation while psychomotor impairment persists, and may interfere with sleep.
What this interaction means in plain words
Lisdexamfetamine and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects (GABA-A potentiation versus catecholamine release); no significant pharmacokinetic interaction.
What to do
Take lisdexamfetamine in the morning and advise against driving after triazolam. Reassess the need for the hypnotic if insomnia is stimulant-related.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Triazolam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triazolam is a short-acting benzodiazepine hypnotic, whereas lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask sedation while psychomotor impairment persists, and may interfere with sleep.
How serious is the interaction between Lisdexamfetamine and Triazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take lisdexamfetamine in the morning and advise against driving after triazolam. Reassess the need for the hypnotic if insomnia is stimulant-related.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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