Drug interactions
Lisdexamfetamine + Triclofos
Severity: Minor
Lisdexamfetamine and Triclofos: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, while lisdexamfetamine is a stimulant, so their effects on alertness oppose each other. Stimulant effects may disrupt sleep and mask sedation without eliminating impairment.
What this interaction means in plain words
Lisdexamfetamine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects; no established pharmacokinetic interaction.
What to do
Give lisdexamfetamine early in the day and counsel about residual impairment after the hypnotic. Reassess the need for the sedative if insomnia is stimulant-induced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Triclofos?
MediHelp rates the interaction as minor. Lisdexamfetamine and Triclofos have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, while lisdexamfetamine is a stimulant, so their effects on alertness oppose each other. Stimulant effects may disrupt sleep and mask sedation without eliminating impairment.
How serious is the interaction between Lisdexamfetamine and Triclofos?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give lisdexamfetamine early in the day and counsel about residual impairment after the hypnotic. Reassess the need for the sedative if insomnia is stimulant-induced.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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