Drug interactions
Lisdexamfetamine + Xylometazoline
Severity: Moderate
Lisdexamfetamine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is converted to amphetamine, which raises blood pressure and heart rate. Xylometazoline can add vasopressor effect if absorbed systemically. Patients with hypertension or arrhythmia are most at risk.
What this interaction means in plain words
Lisdexamfetamine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Xylometazoline belongs to Respiratory.
Why it happens
Additive sympathomimetic effects, with amphetamine-induced norepinephrine release and direct alpha-agonism.
What to do
Monitor blood pressure and heart rate and keep decongestant use short. Consider a non-sympathomimetic alternative such as saline or intranasal corticosteroid in patients with hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Xylometazoline?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is converted to amphetamine, which raises blood pressure and heart rate. Xylometazoline can add vasopressor effect if absorbed systemically. Patients with hypertension or arrhythmia are most at risk.
How serious is the interaction between Lisdexamfetamine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and keep decongestant use short. Consider a non-sympathomimetic alternative such as saline or intranasal corticosteroid in patients with hypertension.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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