Drug interactions
Lisdexamfetamine + Yohimbe
Severity: Major
Lisdexamfetamine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine blocks alpha-2 receptors and increases norepinephrine release, and amphetamine adds further catecholamine release. Together they can cause marked hypertension, tachycardia, anxiety and arrhythmia.
What this interaction means in plain words
Lisdexamfetamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic stimulation through alpha-2 antagonism and amphetamine-induced catecholamine release.
What to do
Advise patients to avoid yohimbe-containing supplements while taking amphetamines; if exposure has occurred, monitor blood pressure and heart rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Yohimbe?
MediHelp rates the interaction as major. Lisdexamfetamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine blocks alpha-2 receptors and increases norepinephrine release, and amphetamine adds further catecholamine release. Together they can cause marked hypertension, tachycardia, anxiety and arrhythmia.
How serious is the interaction between Lisdexamfetamine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe-containing supplements while taking amphetamines; if exposure has occurred, monitor blood pressure and heart rhythm.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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