Drug interactions
Lisinopril + Pregabalin
Severity: Moderate
Lisinopril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with angioedema of the face, lips, tongue and throat. Used together the risk may be increased, and airway swelling can be life-threatening.
What this interaction means in plain words
Lisinopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
ACE inhibitors cause bradykinin accumulation; pregabalin angioedema is rare and its mechanism is not established, so additive risk is largely theoretical.
What to do
The combination can generally be used; counsel patients to seek urgent care for facial or throat swelling. Stop both drugs and manage the airway if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Lisinopril with Pregabalin?
MediHelp rates the interaction as moderate. Lisinopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with angioedema of the face, lips, tongue and throat. Used together the risk may be increased, and airway swelling can be life-threatening.
How serious is the interaction between Lisinopril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can generally be used; counsel patients to seek urgent care for facial or throat swelling. Stop both drugs and manage the airway if angioedema occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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