Drug interactions
Lisinopril + Temsirolimus
Severity: Major
Lisinopril and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus, an mTOR inhibitor, has been associated with angioedema, and the risk appears higher with concurrent ACE inhibitors. Swelling of the face, tongue or airway can be serious.
What this interaction means in plain words
Lisinopril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisinopril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive impairment of bradykinin degradation leading to bradykinin-mediated angioedema.
What to do
Warn patients to report swelling of the lips, face, tongue or throat immediately. Stop lisinopril and switch to a non-ACE inhibitor antihypertensive if angioedema develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Lisinopril with Temsirolimus?
MediHelp rates the interaction as major. Lisinopril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temsirolimus, an mTOR inhibitor, has been associated with angioedema, and the risk appears higher with concurrent ACE inhibitors. Swelling of the face, tongue or airway can be serious.
How serious is the interaction between Lisinopril and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients to report swelling of the lips, face, tongue or throat immediately. Stop lisinopril and switch to a non-ACE inhibitor antihypertensive if angioedema develops.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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