Drug interactions
Lisuride + Metoclopramide
Severity: Major
Lisuride and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisuride is a dopamine agonist used in Parkinson disease and migraine, whereas metoclopramide blocks central dopamine D2 receptors. Metoclopramide can therefore reduce the antiparkinsonian effect of lisuride and may worsen motor symptoms.
What this interaction means in plain words
Lisuride and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors between the D2 antagonist metoclopramide and the dopamine agonist lisuride.
What to do
Avoid metoclopramide in patients taking lisuride for parkinsonism; use an antiemetic without central D2 blockade such as domperidone (where available) or ondansetron, noting QT considerations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Lisuride with Metoclopramide?
MediHelp rates the interaction as major. Lisuride and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisuride is a dopamine agonist used in Parkinson disease and migraine, whereas metoclopramide blocks central dopamine D2 receptors. Metoclopramide can therefore reduce the antiparkinsonian effect of lisuride and may worsen motor symptoms.
How serious is the interaction between Lisuride and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metoclopramide in patients taking lisuride for parkinsonism; use an antiemetic without central D2 blockade such as domperidone (where available) or ondansetron, noting QT considerations.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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