Drug interactions
Lithium + Posaconazole
Severity: Moderate
Lithium and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium has been associated with QT prolongation and conduction abnormalities, particularly at high serum concentrations. Added to posaconazole, this could modestly increase arrhythmia risk, especially with electrolyte disturbance or renal impairment.
What this interaction means in plain words
Lithium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG, keep lithium levels within the therapeutic range and correct potassium and magnesium. Repeat the ECG if symptoms such as palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Posaconazole?
MediHelp rates the interaction as moderate. Lithium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium has been associated with QT prolongation and conduction abnormalities, particularly at high serum concentrations. Added to posaconazole, this could modestly increase arrhythmia risk, especially with electrolyte disturbance or renal impairment.
How serious is the interaction between Lithium and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, keep lithium levels within the therapeutic range and correct potassium and magnesium. Repeat the ECG if symptoms such as palpitations or syncope occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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