Drug interactions
Lithium + Sotagliflozin
Severity: Moderate
Lithium and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors may lower serum lithium concentrations, potentially reducing mood stabilizer control. Changes in volume status and renal sodium handling may also alter lithium clearance.
What this interaction means in plain words
Lithium and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Sotagliflozin belongs to Endocrine.
Why it happens
Likely altered renal handling of lithium due to the effects of SGLT2 inhibition on sodium and volume balance; the mechanism is not fully established.
What to do
Measure serum lithium more often when starting sotagliflozin and after dose changes. Adjust the lithium dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Lithium with Sotagliflozin?
MediHelp rates the interaction as moderate. Lithium and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors may lower serum lithium concentrations, potentially reducing mood stabilizer control. Changes in volume status and renal sodium handling may also alter lithium clearance.
How serious is the interaction between Lithium and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum lithium more often when starting sotagliflozin and after dose changes. Adjust the lithium dose according to levels and clinical response.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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