Drug interactions
Lofepramine + Posaconazole
Severity: Moderate
Lofepramine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may prolong the QT interval, so co-use may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Lofepramine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and recheck the QTc after starting. Choose an alternative if the QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Lofepramine with Posaconazole?
MediHelp rates the interaction as moderate. Lofepramine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may prolong the QT interval, so co-use may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Lofepramine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and recheck the QTc after starting. Choose an alternative if the QTc rises significantly.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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