Drug interactions
Lofepramine + Propofol
Severity: Moderate
Lofepramine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with mild sedative and anticholinergic properties, and it may increase propofol-induced sedation and hypotension. Arrhythmia risk is a lesser concern.
What this interaction means in plain words
Lofepramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension from H1 and alpha-1 blockade combined with GABA-A potentiation.
What to do
Titrate propofol to effect and monitor blood pressure, ECG and sedation level, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Lofepramine with Propofol?
MediHelp rates the interaction as moderate. Lofepramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with mild sedative and anticholinergic properties, and it may increase propofol-induced sedation and hypotension. Arrhythmia risk is a lesser concern.
How serious is the interaction between Lofepramine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor blood pressure, ECG and sedation level, particularly in older patients.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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