Drug interactions
Lofexidine + Lopinavir
Severity: Moderate
Lofexidine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT and PR intervals, and lofexidine also prolongs QT and slows heart rate. Combined use may increase the risk of arrhythmia.
What this interaction means in plain words
Lofexidine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation; ritonavir may also raise lofexidine levels through CYP2D6 inhibition.
What to do
Obtain a baseline ECG and monitor QTc and heart rate, correcting electrolyte abnormalities. Consider a lofexidine dose reduction if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lofexidine with Lopinavir?
MediHelp rates the interaction as moderate. Lofexidine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT and PR intervals, and lofexidine also prolongs QT and slows heart rate. Combined use may increase the risk of arrhythmia.
How serious is the interaction between Lofexidine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate, correcting electrolyte abnormalities. Consider a lofexidine dose reduction if bradycardia or hypotension develops.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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