Drug interactions
Lofexidine + Methamphetamine
Severity: Moderate
Lofexidine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is an alpha-2 agonist that causes sedation, hypotension, and bradycardia, while methamphetamine produces stimulation and hypertension. The opposing effects make hemodynamic response unpredictable, and lofexidine also prolongs the QT interval.
What this interaction means in plain words
Lofexidine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Opposing central and peripheral adrenergic effects, with QT prolongation from lofexidine.
What to do
Monitor blood pressure, heart rate and ECG when the combination is used, particularly at initiation and during dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Methamphetamine?
MediHelp rates the interaction as moderate. Lofexidine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is an alpha-2 agonist that causes sedation, hypotension, and bradycardia, while methamphetamine produces stimulation and hypertension. The opposing effects make hemodynamic response unpredictable, and lofexidine also prolongs the QT interval.
How serious is the interaction between Lofexidine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when the combination is used, particularly at initiation and during dose changes.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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