Drug interactions
Lofexidine + Mirtazapine
Severity: Moderate
Lofexidine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is sedating and causes hypotension, bradycardia and QT prolongation, and mirtazapine adds sedation and a modest QT effect. The combination may increase drowsiness, hypotension and arrhythmia risk.
What this interaction means in plain words
Lofexidine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive QT prolongation, with lofexidine's alpha-2 agonist effects adding hypotension and bradycardia.
What to do
Check ECG and electrolytes at baseline in patients with cardiac risk factors and monitor blood pressure and heart rate. Reduce the lofexidine dose or reconsider the combination if excessive sedation, hypotension or QTc prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Mirtazapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Mirtazapine?
MediHelp rates the interaction as moderate. Lofexidine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is sedating and causes hypotension, bradycardia and QT prolongation, and mirtazapine adds sedation and a modest QT effect. The combination may increase drowsiness, hypotension and arrhythmia risk.
How serious is the interaction between Lofexidine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline in patients with cardiac risk factors and monitor blood pressure and heart rate. Reduce the lofexidine dose or reconsider the combination if excessive sedation, hypotension or QTc prolongation develops.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
