Drug interactions
Lofexidine + Ozanimod
Severity: Major
Lofexidine and Ozanimod: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine prolongs QT and slows heart rate, and ozanimod can also slow heart rate at initiation. Together they may increase the risk of bradycardia and arrhythmia.
What this interaction means in plain words
Lofexidine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lofexidine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive bradycardic and QT-prolonging effects.
What to do
Avoid starting ozanimod in patients taking lofexidine unless the benefit outweighs the risk, and obtain an ECG and monitor heart rate beforehand. Seek cardiology advice if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Zeposia 0.23 mg hard capsules - SmPC sections 4.3/4.5 (class statement: other bradycardic medicinal products; "Patients on other bradycardic medicinal products and on antiarrhythmic medicinal products (which have been associated with cases of torsades de pointes in patie") — electronic medicines compendium (UK SmPC)
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Lofexidine with Ozanimod?
MediHelp rates the interaction as major. Lofexidine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine prolongs QT and slows heart rate, and ozanimod can also slow heart rate at initiation. Together they may increase the risk of bradycardia and arrhythmia.
How serious is the interaction between Lofexidine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients taking lofexidine unless the benefit outweighs the risk, and obtain an ECG and monitor heart rate beforehand. Seek cardiology advice if needed.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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