Drug interactions
Lofexidine + Sotalol
Severity: Major
Lofexidine and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers heart rate and blood pressure and can prolong the QT interval, and sotalol has beta-blocking and QT-prolonging effects. Together they raise the risk of marked bradycardia, hypotension, syncope and torsades de pointes.
What this interaction means in plain words
Lofexidine and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lofexidine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive heart rate and blood pressure lowering plus additive QT prolongation.
What to do
Avoid the combination where possible and consider other options for opioid withdrawal symptoms. If used, monitor ECG, heart rate and blood pressure and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Sotalol?
MediHelp rates the interaction as major. Lofexidine and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine lowers heart rate and blood pressure and can prolong the QT interval, and sotalol has beta-blocking and QT-prolonging effects. Together they raise the risk of marked bradycardia, hypotension, syncope and torsades de pointes.
How serious is the interaction between Lofexidine and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider other options for opioid withdrawal symptoms. If used, monitor ECG, heart rate and blood pressure and correct electrolytes.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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