Drug interactions
Lofexidine + Triclabendazole
Severity: Moderate
Lofexidine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole has been associated with QT prolongation, and lofexidine can also lengthen the QT interval. Using both may increase the risk of ventricular arrhythmias, especially in patients with other cardiac risk factors.
What this interaction means in plain words
Lofexidine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive prolongation of the QTc interval.
What to do
Obtain an ECG before treatment and check potassium and magnesium. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Lofexidine with Triclabendazole?
MediHelp rates the interaction as moderate. Lofexidine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole has been associated with QT prolongation, and lofexidine can also lengthen the QT interval. Using both may increase the risk of ventricular arrhythmias, especially in patients with other cardiac risk factors.
How serious is the interaction between Lofexidine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before treatment and check potassium and magnesium. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk factors.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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