Drug interactions
Lofexidine + Valbenazine
Severity: Moderate
Lofexidine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and lofexidine also prolongs the QT interval. Together they may raise the risk of torsades de pointes, especially in patients with bradycardia, electrolyte disturbances or reduced CYP2D6 or CYP3A4 clearance of valbenazine.
What this interaction means in plain words
Lofexidine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QTc interval.
What to do
Check a baseline ECG and electrolytes and repeat the ECG after starting therapy. Avoid the combination in congenital long QT syndrome or a history of arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Lofexidine with Valbenazine?
MediHelp rates the interaction as moderate. Lofexidine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and lofexidine also prolongs the QT interval. Together they may raise the risk of torsades de pointes, especially in patients with bradycardia, electrolyte disturbances or reduced CYP2D6 or CYP3A4 clearance of valbenazine.
How serious is the interaction between Lofexidine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG after starting therapy. Avoid the combination in congenital long QT syndrome or a history of arrhythmia.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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