Drug interactions
Lomitapide + Methoxsalen
Severity: Moderate
Lomitapide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen can inhibit CYP3A4 and may raise lomitapide exposure. Higher lomitapide levels increase the risk of gastrointestinal adverse effects and hepatotoxicity.
What this interaction means in plain words
Lomitapide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Methoxsalen inhibits CYP3A4, reducing the metabolism of lomitapide.
What to do
Monitor liver enzymes and gastrointestinal tolerance, and keep the lomitapide dose within labeled limits for concomitant weak CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Methoxsalen?
MediHelp rates the interaction as moderate. Lomitapide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen can inhibit CYP3A4 and may raise lomitapide exposure. Higher lomitapide levels increase the risk of gastrointestinal adverse effects and hepatotoxicity.
How serious is the interaction between Lomitapide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerance, and keep the lomitapide dose within labeled limits for concomitant weak CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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