Drug interactions
Lomitapide + Orphenadrin
Severity: Minor
Lomitapide and Orphenadrin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide exposure is strongly increased by CYP3A4 inhibitors, but orphenadrine is not an established significant CYP3A4 inhibitor. Any effect is likely small, though lomitapide hepatotoxicity warrants attention.
What this interaction means in plain words
Lomitapide and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Orphenadrin belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition; not clearly established.
What to do
Monitor liver enzymes as per lomitapide labeling and watch for gastrointestinal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orphenadrin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Orphenadrin?
MediHelp rates the interaction as minor. Lomitapide and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide exposure is strongly increased by CYP3A4 inhibitors, but orphenadrine is not an established significant CYP3A4 inhibitor. Any effect is likely small, though lomitapide hepatotoxicity warrants attention.
How serious is the interaction between Lomitapide and Orphenadrin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes as per lomitapide labeling and watch for gastrointestinal adverse effects.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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