Drug interactions
Lomitapide + Paclitaxel
Severity: Moderate
Lomitapide and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and could increase paclitaxel exposure. Clinical data are lacking and the effect is predicted from in vitro properties.
What this interaction means in plain words
Lomitapide and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Lomitapide inhibits P-glycoprotein, decreasing paclitaxel efflux.
What to do
Monitor for paclitaxel toxicity, particularly myelosuppression and neuropathy, and reduce the dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Paclitaxel?
MediHelp rates the interaction as moderate. Lomitapide and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and could increase paclitaxel exposure. Clinical data are lacking and the effect is predicted from in vitro properties.
How serious is the interaction between Lomitapide and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paclitaxel toxicity, particularly myelosuppression and neuropathy, and reduce the dose if it occurs.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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