Drug interactions
Lomitapide + Quinidine
Severity: Contraindicated
Lomitapide and Quinidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is extensively metabolized by CYP3A4, and quinidine inhibits this enzyme, so lomitapide exposure may rise considerably. This raises the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Lomitapide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lomitapide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated lomitapide metabolism, increasing exposure.
What to do
Avoid the combination; choose a different antiarrhythmic, or reassess lipid-lowering strategy if quinidine is essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Quinidine?
MediHelp rates the interaction as contraindicated. Lomitapide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is extensively metabolized by CYP3A4, and quinidine inhibits this enzyme, so lomitapide exposure may rise considerably. This raises the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Lomitapide and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a different antiarrhythmic, or reassess lipid-lowering strategy if quinidine is essential.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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