Drug interactions
Lomitapide + Saxagliptin-metformin
Severity: Minor
Lomitapide and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may raise exposure to saxagliptin, which is a P-gp substrate. The clinical significance is probably modest, since saxagliptin has a wide margin of safety.
What this interaction means in plain words
Lomitapide and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Lomitapide inhibits P-glycoprotein efflux, potentially increasing saxagliptin absorption and reducing its elimination.
What to do
Monitor for saxagliptin adverse effects such as hypersensitivity or pancreatitis symptoms, and reduce the saxagliptin dose if these emerge. Lomitapide labeling advises dose reduction of P-gp substrates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Lomitapide and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide inhibits P-glycoprotein and may raise exposure to saxagliptin, which is a P-gp substrate. The clinical significance is probably modest, since saxagliptin has a wide margin of safety.
How serious is the interaction between Lomitapide and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects such as hypersensitivity or pancreatitis symptoms, and reduce the saxagliptin dose if these emerge. Lomitapide labeling advises dose reduction of P-gp substrates.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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