Drug interactions
Lomitapide + Sertraline
Severity: Moderate
Lomitapide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and sertraline is a weak CYP3A4 inhibitor. Raised lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Lomitapide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by sertraline reduces lomitapide clearance.
What to do
Monitor liver enzymes and gastrointestinal tolerability, and reduce the lomitapide dose if transaminases rise. Avoid adding stronger CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Sertraline?
MediHelp rates the interaction as moderate. Lomitapide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate, and sertraline is a weak CYP3A4 inhibitor. Raised lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Lomitapide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability, and reduce the lomitapide dose if transaminases rise. Avoid adding stronger CYP3A4 inhibitors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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