Drug interactions
Lomitapide + Vinblastine
Severity: Moderate
Lomitapide and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may raise vinblastine exposure, increasing the risk of myelosuppression and neurotoxicity. Vinblastine is a weak CYP3A4 substrate and any effect on lomitapide exposure is not well established, so the clinical relevance is mainly in the vinblastine direction.
What this interaction means in plain words
Lomitapide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Lomitapide inhibits P-glycoprotein efflux of vinblastine, which may increase vinblastine systemic exposure.
What to do
Monitor blood counts and signs of neurotoxicity or gastrointestinal toxicity, and consider reducing the vinblastine dose if toxicity appears. Monitor liver enzymes as usual for lomitapide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Vinblastine?
MediHelp rates the interaction as moderate. Lomitapide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may raise vinblastine exposure, increasing the risk of myelosuppression and neurotoxicity. Vinblastine is a weak CYP3A4 substrate and any effect on lomitapide exposure is not well established, so the clinical relevance is mainly in the vinblastine direction.
How serious is the interaction between Lomitapide and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neurotoxicity or gastrointestinal toxicity, and consider reducing the vinblastine dose if toxicity appears. Monitor liver enzymes as usual for lomitapide.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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