Drug interactions
Lomitapide + Warfarin
Severity: Major
Lomitapide and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide can increase warfarin effect and raise the INR. This increases the risk of bleeding if the warfarin dose is not adjusted. The effect is labeled and clinically relevant.
What this interaction means in plain words
Lomitapide and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomitapide belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not fully established; lomitapide appears to increase warfarin anticoagulant effect, possibly via altered warfarin exposure or vitamin K status.
What to do
Monitor INR regularly, especially when starting lomitapide or changing its dose. Adjust the warfarin dose to maintain the target INR.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Lomitapide with Warfarin?
MediHelp rates the interaction as major. Lomitapide and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide can increase warfarin effect and raise the INR. This increases the risk of bleeding if the warfarin dose is not adjusted. The effect is labeled and clinically relevant.
How serious is the interaction between Lomitapide and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR regularly, especially when starting lomitapide or changing its dose. Adjust the warfarin dose to maintain the target INR.
What other medicines interact with Lomitapide?
MediHelp also lists interactions of Lomitapide with, for example, Aprepitant, Clarithromycin, Crizotinib. The full list is on the Lomitapide page.
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