Drug interactions
Lomitapide + Ziprasidone
Severity: Minor
Lomitapide and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is a weak CYP3A4 inhibitor at most, so the effect on lomitapide exposure is expected to be small. Lomitapide is highly sensitive to CYP3A4 inhibition, and its exposure may rise slightly, increasing the risk of liver enzyme elevation and gastrointestinal effects.
What this interaction means in plain words
Lomitapide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition reducing lomitapide metabolism; the effect of ziprasidone is not well established.
What to do
Monitor liver enzymes according to lomitapide labeling and watch for gastrointestinal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Ziprasidone?
MediHelp rates the interaction as minor. Lomitapide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone is a weak CYP3A4 inhibitor at most, so the effect on lomitapide exposure is expected to be small. Lomitapide is highly sensitive to CYP3A4 inhibition, and its exposure may rise slightly, increasing the risk of liver enzyme elevation and gastrointestinal effects.
How serious is the interaction between Lomitapide and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes according to lomitapide labeling and watch for gastrointestinal adverse effects.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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