Drug interactions
Lomustine + Meningococcal a c y and w-135 polysaccharide vaccine combined
Severity: Moderate
Lomustine and Meningococcal a c y and w-135 polysaccharide vaccine combined: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine immunosuppression may reduce the antibody response to meningococcal polysaccharide vaccine, leaving patients less protected against invasive disease.
What this interaction means in plain words
Lomustine and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Vaccinate at least 2 weeks before lomustine when possible; otherwise revaccinate about 3 months after therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates the interaction as moderate. Lomustine and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine immunosuppression may reduce the antibody response to meningococcal polysaccharide vaccine, leaving patients less protected against invasive disease.
How serious is the interaction between Lomustine and Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before lomustine when possible; otherwise revaccinate about 3 months after therapy ends.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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