Drug interactions
Lomustine + Pneumococcal vaccine heptavalent
Severity: Moderate
Lomustine and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes myelosuppression and impairs immune function, so the antibody response to a pneumococcal conjugate vaccine may be weaker than normal. Patients may therefore be left with inadequate protection against pneumococcal disease.
What this interaction means in plain words
Lomustine and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppressive and immunosuppressive effects of lomustine blunt the humoral response to vaccination.
What to do
Where possible, give the vaccine at least 2 weeks before starting lomustine. If vaccinated during or shortly before therapy, consider revaccination after immune recovery, typically at least 3 months after chemotherapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Lomustine and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes myelosuppression and impairs immune function, so the antibody response to a pneumococcal conjugate vaccine may be weaker than normal. Patients may therefore be left with inadequate protection against pneumococcal disease.
How serious is the interaction between Lomustine and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine at least 2 weeks before starting lomustine. If vaccinated during or shortly before therapy, consider revaccination after immune recovery, typically at least 3 months after chemotherapy ends.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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