Drug interactions
Lomustine + Poliovirus vaccine inactivated
Severity: Minor
Lomustine and Poliovirus vaccine inactivated: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with lomustine can blunt the antibody response to inactivated poliovirus vaccine. The vaccine is not live, so the concern is reduced efficacy rather than infection from the vaccine.
What this interaction means in plain words
Lomustine and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lomustine-induced immunosuppression reduces the immune response to the inactivated antigen.
What to do
Avoid vaccinating during chemotherapy if possible, and ideally vaccinate at least 2 weeks before starting. Revaccinate at least 3 months after therapy ends if immune competence has recovered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Poliovirus vaccine inactivated?
MediHelp rates the interaction as minor. Lomustine and Poliovirus vaccine inactivated have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chemotherapy with lomustine can blunt the antibody response to inactivated poliovirus vaccine. The vaccine is not live, so the concern is reduced efficacy rather than infection from the vaccine.
How serious is the interaction between Lomustine and Poliovirus vaccine inactivated?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccinating during chemotherapy if possible, and ideally vaccinate at least 2 weeks before starting. Revaccinate at least 3 months after therapy ends if immune competence has recovered.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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