Drug interactions
Lomustine + Rabies vaccine
Severity: Moderate
Lomustine and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine can diminish the antibody response to rabies vaccine. This matters because inadequate rabies immunity can be fatal after exposure.
What this interaction means in plain words
Lomustine and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression from lomustine impairs the humoral response to vaccination.
What to do
For post-exposure use, do not delay vaccination, and measure rabies neutralizing antibody titers to confirm response. For pre-exposure vaccination, give it at least 2 weeks before lomustine or revaccinate after recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Rabies vaccine?
MediHelp rates the interaction as moderate. Lomustine and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine can diminish the antibody response to rabies vaccine. This matters because inadequate rabies immunity can be fatal after exposure.
How serious is the interaction between Lomustine and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For post-exposure use, do not delay vaccination, and measure rabies neutralizing antibody titers to confirm response. For pre-exposure vaccination, give it at least 2 weeks before lomustine or revaccinate after recovery.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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