Drug interactions
Lomustine + Tetanus toxoid adsorbed or fluid
Severity: Minor
Lomustine and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine may reduce the antibody response to tetanus toxoid. The patient may have weaker or shorter-lived protection against tetanus.
What this interaction means in plain words
Lomustine and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic immunosuppression by lomustine reduces the response to the toxoid antigen.
What to do
Vaccinate at least 2 weeks before starting lomustine when possible. Revaccinate at least 3 months after chemotherapy if the dose was given during or shortly before treatment, and still treat wounds per standard tetanus prophylaxis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Lomustine and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomustine may reduce the antibody response to tetanus toxoid. The patient may have weaker or shorter-lived protection against tetanus.
How serious is the interaction between Lomustine and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting lomustine when possible. Revaccinate at least 3 months after chemotherapy if the dose was given during or shortly before treatment, and still treat wounds per standard tetanus prophylaxis.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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