Drug interactions
Lomustine + Thiotepa
Severity: Major
Lomustine and Thiotepa: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are alkylating cytotoxics with dose-limiting bone marrow toxicity. Used together they can produce deeper and longer-lasting neutropenia, thrombocytopenia and anemia, raising the risk of infection and bleeding.
What this interaction means in plain words
Lomustine and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomustine belongs to Oncology; Thiotepa belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression from two DNA-alkylating agents.
What to do
Monitor complete blood counts frequently, including the nadir period, and reduce doses or delay cycles for marked cytopenias. Provide supportive care such as growth factors and transfusion as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Lomustine with Thiotepa?
MediHelp rates the interaction as major. Lomustine and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are alkylating cytotoxics with dose-limiting bone marrow toxicity. Used together they can produce deeper and longer-lasting neutropenia, thrombocytopenia and anemia, raising the risk of infection and bleeding.
How serious is the interaction between Lomustine and Thiotepa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, including the nadir period, and reduce doses or delay cycles for marked cytopenias. Provide supportive care such as growth factors and transfusion as indicated.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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