Drug interactions
Lomustine + Typhoid polysaccharide vaccine
Severity: Moderate
Lomustine and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The typhoid polysaccharide vaccine is inactivated, so there is no replication risk, but lomustine-related immunosuppression may reduce the antibody response and leave the patient inadequately protected.
What this interaction means in plain words
Lomustine and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression blunts the humoral response to vaccination.
What to do
Vaccinate at least 2 weeks before chemotherapy when possible; otherwise give the vaccine but do not rely on it and keep up food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Lomustine and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The typhoid polysaccharide vaccine is inactivated, so there is no replication risk, but lomustine-related immunosuppression may reduce the antibody response and leave the patient inadequately protected.
How serious is the interaction between Lomustine and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when possible; otherwise give the vaccine but do not rely on it and keep up food and water precautions.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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