Drug interactions
Lomustine + Zoster vaccine recombinant
Severity: Minor
Lomustine and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine can blunt the response to recombinant zoster vaccine. The vaccine is non-live and so is not unsafe, but protection may be reduced.
What this interaction means in plain words
Lomustine and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lomustine-induced immunosuppression diminishes the immune response to the vaccine antigen.
What to do
Ideally vaccinate before starting lomustine, or time the doses when blood counts have recovered. Consider revaccination after treatment if immune response was likely impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Lomustine and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomustine can blunt the response to recombinant zoster vaccine. The vaccine is non-live and so is not unsafe, but protection may be reduced.
How serious is the interaction between Lomustine and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ideally vaccinate before starting lomustine, or time the doses when blood counts have recovered. Consider revaccination after treatment if immune response was likely impaired.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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