Drug interactions
Lonafarnib + Methoxsalen
Severity: Moderate
Lonafarnib and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and methoxsalen can inhibit CYP3A4. Higher lonafarnib levels may increase gastrointestinal toxicity, and its effect on cardiac conduction is not fully characterized.
What this interaction means in plain words
Lonafarnib and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Methoxsalen belongs to Anti Fungals.
Why it happens
Methoxsalen inhibition of CYP3A4 reduces lonafarnib metabolism.
What to do
Avoid if feasible, otherwise continue lonafarnib at the starting or reduced dose per labeling. Monitor for adverse effects and for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Methoxsalen?
MediHelp rates the interaction as moderate. Lonafarnib and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and methoxsalen can inhibit CYP3A4. Higher lonafarnib levels may increase gastrointestinal toxicity, and its effect on cardiac conduction is not fully characterized.
How serious is the interaction between Lonafarnib and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible, otherwise continue lonafarnib at the starting or reduced dose per labeling. Monitor for adverse effects and for palpitations or syncope.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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