Drug interactions
Lonafarnib + Mifepristone
Severity: Major
Lonafarnib and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate and mifepristone inhibits CYP3A4. Higher lonafarnib exposure may increase gastrointestinal toxicity, electrolyte disturbances and QT effects.
What this interaction means in plain words
Lonafarnib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lonafarnib belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, decreasing the metabolism of lonafarnib.
What to do
Avoid concurrent use; choose an alternative to mifepristone if possible. If it cannot be avoided, reduce the lonafarnib dose per labeling and monitor for toxicity and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Mifepristone?
MediHelp rates the interaction as major. Lonafarnib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A4 substrate and mifepristone inhibits CYP3A4. Higher lonafarnib exposure may increase gastrointestinal toxicity, electrolyte disturbances and QT effects.
How serious is the interaction between Lonafarnib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative to mifepristone if possible. If it cannot be avoided, reduce the lonafarnib dose per labeling and monitor for toxicity and QTc.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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