Drug interactions
Lonafarnib + Nicardipine
Severity: Moderate
Lonafarnib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and nicardipine may modestly increase its levels. Higher lonafarnib exposure may worsen GI toxicity and has unknown effects on QT interval.
What this interaction means in plain words
Lonafarnib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine weakly inhibits CYP3A4, decreasing lonafarnib clearance.
What to do
Monitor for GI toxicity, palpitations or syncope, and consider an antihypertensive that does not inhibit CYP3A4. If unavoidable, keep lonafarnib at the lower dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Nicardipine?
MediHelp rates the interaction as moderate. Lonafarnib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and nicardipine may modestly increase its levels. Higher lonafarnib exposure may worsen GI toxicity and has unknown effects on QT interval.
How serious is the interaction between Lonafarnib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI toxicity, palpitations or syncope, and consider an antihypertensive that does not inhibit CYP3A4. If unavoidable, keep lonafarnib at the lower dose per labeling.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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