Drug interactions
Lonafarnib + Nizatidine
Severity: Minor
Lonafarnib and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine is not a meaningful CYP3A4 inhibitor, so a pharmacokinetic effect on lonafarnib is unlikely. The legacy concern appears to be class-based and not supported by known pharmacology.
What this interaction means in plain words
Lonafarnib and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; nizatidine does not significantly inhibit CYP3A4.
What to do
No adjustment is needed; monitor for lonafarnib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Nizatidine?
MediHelp rates the interaction as minor. Lonafarnib and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine is not a meaningful CYP3A4 inhibitor, so a pharmacokinetic effect on lonafarnib is unlikely. The legacy concern appears to be class-based and not supported by known pharmacology.
How serious is the interaction between Lonafarnib and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for lonafarnib adverse effects as usual.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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