Drug interactions
Lonafarnib + Paclitaxel
Severity: Moderate
Lonafarnib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and a CYP3A inhibitor, so paclitaxel exposure could rise somewhat. The effect is expected to be modest.
What this interaction means in plain words
Lonafarnib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
Lonafarnib inhibits P-glycoprotein and CYP3A4, reducing paclitaxel efflux and metabolism.
What to do
Monitor blood counts and neuropathy and consider reducing the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Paclitaxel?
MediHelp rates the interaction as moderate. Lonafarnib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a weak P-glycoprotein inhibitor and a CYP3A inhibitor, so paclitaxel exposure could rise somewhat. The effect is expected to be modest.
How serious is the interaction between Lonafarnib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and consider reducing the paclitaxel dose if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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