Drug interactions
Lonafarnib + Prednisone
Severity: Minor
Lonafarnib and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and could slightly raise exposure to P-gp substrates. Prednisone and prednisolone are only modest P-gp substrates, so a clinically relevant change is unlikely.
What this interaction means in plain words
Lonafarnib and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
Weak inhibition of P-glycoprotein efflux may modestly increase prednisone absorption and exposure.
What to do
No dose change is generally needed. Watch for increased corticosteroid adverse effects such as fluid retention or hyperglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Prednisone?
MediHelp rates the interaction as minor. Lonafarnib and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and could slightly raise exposure to P-gp substrates. Prednisone and prednisolone are only modest P-gp substrates, so a clinically relevant change is unlikely.
How serious is the interaction between Lonafarnib and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Watch for increased corticosteroid adverse effects such as fluid retention or hyperglycemia.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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