Drug interactions
Lonafarnib + Roflumilast
Severity: Moderate
Lonafarnib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a CYP3A inhibitor and may raise roflumilast concentrations. This may increase dose-related adverse effects such as diarrhea, weight loss and insomnia.
What this interaction means in plain words
Lonafarnib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Roflumilast belongs to Respiratory.
Why it happens
Lonafarnib inhibits CYP3A4, decreasing roflumilast clearance.
What to do
Monitor for roflumilast adverse effects, especially gastrointestinal and psychiatric symptoms, and consider stopping roflumilast if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Roflumilast?
MediHelp rates the interaction as moderate. Lonafarnib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a CYP3A inhibitor and may raise roflumilast concentrations. This may increase dose-related adverse effects such as diarrhea, weight loss and insomnia.
How serious is the interaction between Lonafarnib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects, especially gastrointestinal and psychiatric symptoms, and consider stopping roflumilast if they develop.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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