Drug interactions
Lonafarnib + Sertraline
Severity: Moderate
Lonafarnib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, but sertraline is only a weak CYP3A4 inhibitor, so the effect is likely modest. Even so, exposure to lonafarnib may rise and increase its gastrointestinal and other adverse effects.
What this interaction means in plain words
Lonafarnib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may reduce lonafarnib metabolism.
What to do
Monitor for lonafarnib adverse effects such as nausea, diarrhea and QT changes, and reduce the dose if poorly tolerated. Avoid additional moderate or strong CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Sertraline?
MediHelp rates the interaction as moderate. Lonafarnib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A4 substrate, but sertraline is only a weak CYP3A4 inhibitor, so the effect is likely modest. Even so, exposure to lonafarnib may rise and increase its gastrointestinal and other adverse effects.
How serious is the interaction between Lonafarnib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects such as nausea, diarrhea and QT changes, and reduce the dose if poorly tolerated. Avoid additional moderate or strong CYP3A4 inhibitors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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