Drug interactions
Lonafarnib + Ticagrelor
Severity: Major
Lonafarnib and Ticagrelor: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and ticagrelor is a weak CYP3A inhibitor that may raise its exposure. Lonafarnib is also a strong CYP3A inhibitor and may increase ticagrelor levels, raising bleeding risk.
What this interaction means in plain words
Lonafarnib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lonafarnib belongs to Miscellaneous; Ticagrelor belongs to Cardiovascular.
Why it happens
Lonafarnib inhibits CYP3A4 raising ticagrelor levels, while ticagrelor weakly inhibits CYP3A4 and may raise lonafarnib levels.
What to do
Avoid the combination if possible and use an alternative antiplatelet. If unavoidable, monitor for bleeding and lonafarnib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ticagrelor?
MediHelp rates the interaction as major. Lonafarnib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a sensitive CYP3A substrate, and ticagrelor is a weak CYP3A inhibitor that may raise its exposure. Lonafarnib is also a strong CYP3A inhibitor and may increase ticagrelor levels, raising bleeding risk.
How serious is the interaction between Lonafarnib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative antiplatelet. If unavoidable, monitor for bleeding and lonafarnib adverse effects.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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