Drug interactions
Lonafarnib + Tinidazole
Severity: Moderate
Lonafarnib and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may raise tinidazole concentrations, since tinidazole is partly cleared via CYP3A4. Higher exposure could increase tinidazole adverse effects such as nausea, metallic taste and neurological symptoms.
What this interaction means in plain words
Lonafarnib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Tinidazole belongs to Anti Parasitic.
Why it happens
Lonafarnib inhibits CYP3A4, reducing the metabolism of tinidazole.
What to do
Monitor for tinidazole adverse effects, particularly gastrointestinal and neurological symptoms, during short courses. Prefer a single-dose or short regimen where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Tinidazole?
MediHelp rates the interaction as moderate. Lonafarnib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may raise tinidazole concentrations, since tinidazole is partly cleared via CYP3A4. Higher exposure could increase tinidazole adverse effects such as nausea, metallic taste and neurological symptoms.
How serious is the interaction between Lonafarnib and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tinidazole adverse effects, particularly gastrointestinal and neurological symptoms, during short courses. Prefer a single-dose or short regimen where appropriate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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