Drug interactions
Lonafarnib + Umeclidinium-vilanterol
Severity: Moderate
Lonafarnib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may increase vilanterol exposure, since vilanterol is a CYP3A4 substrate. Higher levels may cause tachycardia, palpitations, tremor and hypokalemia.
What this interaction means in plain words
Lonafarnib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilanterol, raising its systemic exposure.
What to do
Monitor heart rate, potassium and symptoms of beta-agonist excess during co-use. Consider an alternative bronchodilator regimen if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Lonafarnib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may increase vilanterol exposure, since vilanterol is a CYP3A4 substrate. Higher levels may cause tachycardia, palpitations, tremor and hypokalemia.
How serious is the interaction between Lonafarnib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and symptoms of beta-agonist excess during co-use. Consider an alternative bronchodilator regimen if adverse effects develop.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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